It contains four core components: presenilins, nicastrin, anterior pharynx defective (aph-1) and...
Peptidase AD, alternative name gamma secretase complex plays a pivotal role in the progress of Alzheimer’s disease (AD). They generate the cleavage of amyloid precursor protein (APP) which is the parent molecule of beta amyloid protein (Aß). Peptidase AD is an 18-times transmembrane aspartyl protease to regulate intramembrane proteolysis for a growing list of integral membrane proteins.
Keywords: gamma secretase
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